An important pathophysiologic complication of Corona virus infection is the generation of micro-thrombi in the alveolar structure (radiologically seen as ground glass opacities) possibly accompanied by systemic micro-thrombi in many organs [1-3], the latter being typical for disseminated intravascular coagulation (DIC).
Monocytes/macrophages (MØ) contain high concentrations of the strongest trigger of blood coagulation, that is tissue factor (TF). Therefore, destroyed MØ trigger extrinsic F7a-driven thrombin generation via TF and intrinsic F12a/kallikrein driven thrombin generation via free DNA/phospholipids [4], kallikrein causing capillary leakage. The Corona virus seems to infect and destroy alveolar macrophages or blood monocytes [5-7].