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ES Journal of Case Reports

ISSN: 2767-6560 DOI: 10.59152/ESJCR/1036

Cytokine-Induced Neurogenesis and Angiogenesis Reversed Cognitive Decline in a Vascular Dementia Patient with Hashimoto’s Thyroiditis

  • Case Report

  • Takuji Shirasawa1,*, Luis Carlos Aguilar Cobos2
  • 1Ochanomizu Health and Longevity Clinic, Tokyo, Japan
  • 2Livant Neurorecovery Center, Guadalajara, Mexico
  • *Corresponding author: Takuji Shirasawa, Ochanomizu Health and Longevity Clinic, Tokyo, Japan, e-mail:
  • Received: March 19, 2023;Accepted: April 24, 2023; Published: April 26, 2023


Vascular dementia (VaD) is the second most prevalent cause of dementia in the world after Alzheimer’s disease (AD), but no curative treatment has yet been established. We treated a 70-year-old male Japanese VaD patient with Hashimoto’s thyroiditis using cytokine-induced neurogenesis and angiogenesis to regenerate residual neuronal stem cells and degenerated middle cerebral artery (MCA) branches. This treatment successfully regenerated the atrophied cerebral cortex, hippocampus, and degenerated MCA branches and was associated with improved cognitive function and the resolution of electrophysiological abnormalities. To the best of our knowledge, this is the first case report to demonstrate that cytokine-induced neurogenesis and angiogenesis reversed cognitive decline due to VaD.


Vascular Dementia (VaD), Cytokine, Hashimoto’s Thyroiditis, Neurogenesis, Angiogenesis