This brief report discusses some psychological and cultural aspects of treatment and care at end-of-life, along with suggesting that clinical supervision, along with similar forums, provides protection and development to health care. Beyond technical aspects of treatment and care, clinicians are exposed to existential realities and moral complexities that require cultural sensitivity and test resilience. A concise case example illustrates the emotional resonance of clinical work and risks of identification when working with the seriously ill and the dying. This discussion makes a case for organizational support for formal work discussions, in clinical supervision, throughout oncology and palliative care.