The incidence of depression Combined Coronary Heart Disease (CHD) is increasing, and it is a consensus that depression could increases the incidence of adverse cardiovascular events or mortality. Women under 50 and aging males were the high-risk groups of patients with CHD combined depression, existing researches on the relationship between the depression history, the onset times of depression, the therapeutic schedule and the adverse prognosis of CHD showed great differences; the differences of depression syndromes (somatic/emotional symptoms), CHD subtypes, LVEF levels and estrogen levels in individuals may explain this heterogeneity partly. Autonomic nervous system, limbic system, intestinal micro flora, inflammatory response, metabolism of 5-HT and polyunsaturated fatty acid maybe the main pathological basis for the occurrence and progress of CHD combined depression. In addition, depression severity associate with no nadherence in a gradient fashion, improvement of depression syndromes precedes the improvement of drug compliance.
Coronary heart disease combined depression; Depression; Acute coronary syndrome; Myocardial infarction; Pathogenesis