Hypokalemia is a multifactorial electrolyte abnormalities that could be life-threatening. Identifying the cause is of paramount importance for treatment strategies and prevent complications. Hypokalemia can result from Familial and non-familial causes including hypothyroidism. Here we report a case of a 26 year old Hispanic male who presented with ascending paralysis of the extremities from low potassium level as a result of hyperthyroid state.