Synthetic Cannabinoid Receptor Agonists (SCRAs) are a group of products created using plant products sprayed with chemical agents that act on cannabinoid (CB) receptors. These agents sold as K2 or Spice are a pure agonist on CB receptors and are potent compared to the tetra hydro cannabinol (THC) [1-5]. Several adverse medical and psychiatric effects including seizures, cardiovascular adverse events and as well as hyperthermia and rhabdomyolysis have been reported [6-8]. Here, we report a case of elderly patient with SCRAs-induced hyperthermia and cardiac arrest.