As COVID-19 continues to spread in countries all over the world included Libya, the impact of the disease among children, initially considered less important , will increasingly be more relevant. The role of children in viral transmission and its impact in epidemic expansion, as well as the extent of the diversity of clinical presentation, are still unclear. At the end of April, the United Kingdom South Thames Retrieval Service alerted on a new clinical picture manifesting as a hyper-inflammatory syndrome, with multi-organ involvement similar to Kawasaki Disease and with potential evolution to a shock syndrome. This represented a new phenomenon affecting previously asymptomatic children with SARS-CoV-2 infection . This Multisystem Inflammatory Syndrome in Children (MIS-C) associated with SARS-CoV-2 infection occurs weeks after infection and may evolve unnoticed.