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ES Journal of Microbiology

ISSN: 2768-0584

Computer aided Screening of Phytocompounds from Trigonella foenumgraecum (Fenugreek) Targeting Mutual Sub-cellular Proteins of Bacillus subtilis and Escherichia coli

  • Research Article

  • Sameer Sharma, Supriya Jadhav and Sibi G*
  • Department of Biotechnology, Indian Academy Degree College-Autonomous, India
  • *Corresponding author: Sibi G, Head of the Department, Department of Biotechnology, Indian Academy Degree College-Autonomous, India
  • Received: June 18, 2020; Accepted: June 29, 2020; Published: July 02, 2020

Abstract

Objective: The prediction of bacterial sub-cellular proteins can be considered aid to biotechnological research. Bacterial proteins play a major role in cell division as well as in virulence. Here, we attempt to identify the potential phytocompounds Trigonella foenum-graecum from that can spot those bacterial sub-cellular proteins.

Methodology: Insilico screening for phytoligands from Fenugreek with subjected to molecular docking simulations for better perception of correlation between phytocompounds and the target receptors.

Results: Quercetin, Smilagenin, Diosgenin & Naringenin from Fenugreek possess immense binding affinity against subcellular bacterial proteins.

Conclusion: Based on all outcomes, we assertion that 4 phytoligands (Quercetin, Smilagenin, Diosgenin & Naringenin) could serve as an effective anti-bacterial compounds to cure bacterial infections.

Keywords

Phytocompounds, Sub-cellular proteins, Molecular docking, Fenugreek.