Background: Cystatin C, a marker for early stage chronic kidney dysfunction, mediates the pathogenesis of cardiovascular diseases.
Objectives: To assess the relation between level of serum Cystatin Cand severity of coronary artery disease (CAD) in patients without chronic kidney disease (CKD).
Patients and methods: In this cross-sectional study, we included 80 patients with CAD divided in two groups (group I with acute coronary artery disease and group II with chronic stable coronary artery disease) 40 patients each and acquired their demographic characteristics, medical histories, and listings of the concurrent medications they were taking. All patients with CAD underwent ECG, echocardiography, coronary angiography, serum Cystatin C level, cardiac enzymes and other routine laboratory tests.
Results: As regard demographic data and comorbiditiesthere was no significant difference between the two groups as regard gender, diabetes mellitus, hypertension or smoking.
Also, As regard level of serum Cystatin C, the mean and SD in 1 vessel affection was 0.92±0.07 while in 2 vessels affection was 1.07±0.13 and 3 vessels affection was 1.41±0.05 with (P< 0.01).
Finally, there was a highly significant difference as regard Cystatin C level with mean and SD 1.21±0.18 in ST-segment elevation MI while mean and SD was 0.96±0.09 in Non ST-segment MI or unstable angina with (P< 0.01).
There was a statistically significant correlation between level of Cystatin C and severity of CAD (p < 0.05).
Conclusion: Serum cystatin C has a significant effect on the severity of coronary artery disease (CAD) , being higher in patients with 3 vessels disease and severe CAD.
Coronary Artery Disease, Cystatin C